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Use of Topical Silver Nitrate, Mafenide, and Gentamicin in the Burn PatientA Comparative Study
Bruce G. MacMillan, MD;
Edward O. Hill, PhD;
William A. Altemeier, MD
AMA Arch Surg. 1967;95(3):472-481.
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BURN wound sepsis continues to be the greatest threat to survival for the patient sustaining a major burn.1-4 Since 1962, 562 burn patients have been treated in the Burn Unit of the Cincinnati General Hospital. Deaths during this period have ranged from 10 to 25 a year, and have accounted for an overall yearly mortality rate ranging from 13% to 18%. Deaths from septicemia accounted for 24% to 45% of these deaths. Fatal pulmonary complications ranged from 4% to 33 %. During the year of 1966, fatal septicemia accounted for 24%, and pulmonary infections for 33%, together comprising a total of 57% of the deaths occurring during this period (Table 1).
The chief gram-positive organism causing septicemia since 1960 has been the coagulase-positive Staphylococcus aureus. The gram-negative organisms causing septicemia have included Pseudomonas aeruginosa, Proteus mirabilis, Paracolobactrum aerogenoids, and the Aerobacter-Klebsiella group (Table 2).
During this seven-year period, there has
. . . [Full Text PDF of this Article]
Author Affiliations
Cincinnati
From the Department of Surgery, University of Cincinnati College of Medicine and the Cincinnati General Hospital.
Footnotes
Submitted for publication March 22, 1967.
Read before the 24th annual meeting of the Central Surgical Association, Pittsburgh, Feb 24, 1967.
Reprint requests to Department of Surgery, Cincinnati General Hospital, 3231 Burnet Ave, Cincinnati 45229 (Dr. Altemeier).
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