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Serum and Leukocyte Lysosomal EnzymesDerangements Following Severe Thermal Injury
J. Wesley Alexander, MD, DSc
AMA Arch Surg. 1967;95(3):482-491.
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MANY of the severe metabolic and physiological derangements accompanying large thermal injuries have been controlled by appropriate therapy after definition and characterization of these disorders by clinical observation and laboratory investigation. Disturbances of cellular defense mechanisms, however, have been incompletely characterized, and the relationship of such changes to the subsequent development of infection has not been established. Since the introduction of the lysosomal concept by DeDuve,1 there have been numerous studies which have linked the lysosomal integrity of leukocytes with their capacity to kill ingested organisms following phagocytosis. Lysosomal function has also been linked to self-destructive processes, allergic disorders, inflammatory lesions, and shock, all of which could be of importance in burn injury.2-4
This investigation was done to study the changes in serum and leukocyte lysosomal enzymes in patients with large burn injuries, and to correlate these changes with the development of infection and "burn toxemia." Three enzymes, β-glucuronidase,
. . . [Full Text PDF of this Article]
Author Affiliations
Cincinnati and Fort Sam Houston, Tex
From the Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, and the US Army Surgical Research Unit, Brooke Army Medical Center, Fort Sam Houston, Tex.
Footnotes
Submitted for publication March 15, 1967.
Read before the 24th annual meeting of the Central Surgical Association, Pittsburgh, Feb 24, 1967.
Reprint requests to Department of Surgery, Cincinnati General Hospital, 3231 Burnet Ave, Cincinnati 45229 (Dr. Alexander).
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