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Detection by a New Screening Test

John G. Batsakis, MD; Gerald L. Brody, MD; John D. Bartlett, MD; Dale E. Rice, BS

AMA Arch Surg. 1968;96(2):254-258.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

ORIGIN in the urinary bladder of a pheochromocytoma is an unusual experience of an uncommon neoplasm. Of all pheochromocytomas 5% to 10% are extra-adrenal¹ and to date, 24 cases of this neoplasm in the bladder have been reported.

While it is true that certain features of diagnostic import have been shown to predominate in patients with pheochromocytoma of the bladder,²preoperative substantiation is achieved by biochemical means. This confirmation is of more than academic interest when one considers the high mortality associated with surgical procedures on undiagnosed pheochromocytomas regardless of their location.

Since 1950 when Engel and von Euler³ reported an increased urinary content of noradrenaline and adrenaline in two patients with pheochromocytoma, there has been an extensive recording of developments and assessments of biochemical tests for the diagnosis of this disease. One pressing need, however, remains unfulfilled. A clinicallly satisfactory screening test for pheochromocytoma has yet . . . [Full Text PDF of this Article]

Author Affiliations
Ann Arbor, Mich

From the departments of pathology (Drs. Batsakis, Brody, and Rice) and surgery (Dr. Bartlett), at the University of Michigan Medical Center, Ann Arbor, Mich.

Footnotes
Received for publication Aug. 21, 1967.

Reprint requests to Department of Pathology, University of Michigan Medical Center, Ann Arbor, Mich 48104 (Dr. Batsakis).

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