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Surgical Treatment of Chronic Portal-Systemic Encephalopathy
John L. Cameron, MD;
Frederick W. Engstrom, MD;
Duncan A. Cameron, Sr., MD
AMA Arch Surg. 1968;96(2):269-273.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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THE OCCURRENCE of neuropsychiatric disorders following portacaval anastomosis is in the range of 25%.1 Some of these patients have no further difficulty after the frequently observed postoperative liver decompensation reverses. Of those patients who continue to show signs of ammonia intoxication, the majority can be controlled with protein restriction and antibiotic administration. There are occasional patients, however, who cannot be controlled by diet and drug therapy. In the past these patients have required continual nursing care and have pursued progressive courses of neurologic deterioration leading finally to death. Recently, in an attempt to reduce ammonia formation, which is believed to be instrumental in causing the cerebral changes in patients with chronic portal-systemic encephalopathy, colectomy or colonic exclusion has been performed. A patient treated successfully by subtotal colectomy is reported here, and the experience in the literature reviewed.
Report of a Case
A 56-year-old white woman had a history of
. . . [Full Text PDF of this Article]
Author Affiliations
Baltimore
From the Department of Surgery, Johns Hopkins University School of Medicine, Baltimore (Drs. John L. Cameron and Engstrom), and the departments of medicine and surgery, Oakwood Hospital, Dearborn, Mich (Dr. Duncan A. Cameron).
Footnotes
Submitted for publication June 30, 1967.
Reprint requests to Department of Surgery, Johns Hopkins University School of Medicine, Baltimore 21218 (Dr. John L. Cameron).
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