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Coagulation and Hematologic Changes in the Pig

T. E. Blecher, MB, BCh, MRCPE, MC Path; J. Terblanche, ChM, FRCS, FCS (SA); J. H. Peacock, MD, ChM, FRCS

AMA Arch Surg. 1968;96(3):331-339.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

MOST of the plasma factors responsible for blood coagulation are produced in the liver. It is therefore of interest to follow the maintenance or disruption of this function that occurs in the postoperative period following homotransplantation of a liver to a hepatectomized animal. Such studies provide a clinically useful measure of the protein synthesizing ability of the transplanted liver and also give further insight into the physiological role of this organ. The profile of the coagulative and fibrinolytic changes observed in the otherwise untreated recipient of a liver also provides a basis for the planning of future clinical management of human cases.

Several groups of workers have studied these changes following liver transplantation in dogs (Starzl et al,¹ Von Kaulla et al,² Rutherford and Hardaway,³ and Stremple et al⁴) and in humans (Starzl et al¹ and Von Kaulla et al²). Because of the absence . . . [Full Text PDF of this Article]

Author Affiliations
Bristol, England

From the departments of haematology (Dr. Blecher) and surgery (Drs. Terblanche and Peacock) and the Royal Infirmary (Dr. Blecher), Bristol, England. Dr. Terblanche is presently at the University of Cape Town Medical School, Cape Town, Republic of South Africa.

Footnotes
Submitted for publication Aug 30, 1967.

Reprint requests to Department of Haematology, Royal Infirmary, Bristol 2, England (Dr. Blecher).

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