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Transplantation of Autogenous Half-Joints
Martin A. Entin, MD;
George Daniel, MD;
David Kahn, MD
AMA Arch Surg. 1968;96(3):359-368.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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THE feasibility of whole-joint transplantation as a means of replacement of destroyed joints has long intrigued surgeons interested in reconstruction. Although it has been shown that articular cartilage of autogenous whole joints appears to survive transplantation, it ultimately undergoes progressive destruction.1,2 While the sequence of changes has been studied extensively, the mechanism is not yet understood. It would be considerably more practical, if it were possible, to replace the destroyed joints with homografts, but even without the genetic factors of rejection, the autografts are not able to withstand the long-term effects of transplantation.
In previous experiments from this Department attempts have been made to analyze the factors contributing to the ultimate destruction of articular cartilage.1,3 The following have been considered as possible contributing factors: mechanical stress, disturbance of vascular and nerve supply, and alteration of synovial fluid. However, with whole-joint transplants it was not possible to differentiate the
. . . [Full Text PDF of this Article]
Author Affiliations
Montreal
From the departments of surgery, Royal Victoria Hospital; experimental surgery and pathology, McGill University; and pathology, St. Mary's Hospital, Montreal.
Footnotes
Submitted for publication Nov 28, 1966.
Reprint requests to Royal Victoria Hospital, 687 Pine Ave, W, Montreal, Quebec.
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