This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Léon Strebel, MD; Peter E. Siegler, MD

AMA Arch Surg. 1968;96(3):471-475.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE NECESSITY of submitting data to federal agencies in the process of getting approval for marketing led us to conduct studies in medical student volunteers with several batches of dextran solutions. The size of our study—involving 41 healthy young adults in 59 trials—seems to be sufficiently representative to allow some generalization. The observations made in seven cases point to a type of side effect that might be amenable to premedication with an antihistaminic agent.

Design of Study.

—The quality control of the dextran solutions, as specified in the Defense Medical Purchase Description,¹ consisted of the following procedure: (1) measurement of the sublingual temperature; (2) determination of the bleeding time (Ivy method); and (3) thrombocyte count, all being done before intravenous infusion of 500 ml of dextran solution (into an antebrachial vein) over a period of 45 to 60 minutes (approximately 10 ml/min), and again immediately after the infusion, half . . . [Full Text PDF of this Article]

Author Affiliations
Philadelphia

From the Hahnemann Medical College and Hospital, Philadelphia. Dr. Strebel is now with the Department of Pediatrics, Johns Hopkins Hospital, Baltimore.

Footnotes
Submitted for publication Aug 14, 1967.

Reprint requests to 230 N Broad St, Philadelphia 19102 (Dr. Siegler).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?