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Combined Dietary, Surgical, and Bile Salt-Binding Resin Therapy

Henry Buchwald, MD, PhD; Richard B. Moore, MD; Gerald B. Lee, MD; Ivan D. Frantz, Jr., MD; Richard L. Varco, MD, PhD

AMA Arch Surg. 1968;97(2):275-282.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IN VIEW OF the generally accepted fact that atherosclerosis is related to the concentration of the circulating cholesterol, efforts to prevent, retard, arrest, or reverse the atherosclerotic process have been directed towards cholesterol reduction. There are basically three approaches to cholesterol lowering employed today: diet, drugs, and surgery.

The diet most commonly used to achieve cholesterol reduction is a diet low in cholesterol, with a high ratio of polyunsaturated to saturated fats (P/S ratio). These general principles were derived from the observations of epidemiologists on the importance of dietary constituents in influencing the circulating cholesterol.^1-4 Kinsell et al⁵ studied in a controlled experiment the cholesterol lowering effect of diets containing large amounts of unsaturated fats. Connor et al^6,7 and Grande et al⁸ demonstrated the role of dietary cholesterol in influencing serum cholesterol. The paper of Green et al⁹ on the use of fat-modified foods for . . . [Full Text PDF of this Article]

Author Affiliations
Minneapolis

From the departments of surgery and medicine, University of Minnesota Hospitals, Minneapolis. Dr. Buchwald is an established investigator for the American Heart Association.

Footnotes
Submitted for publication March 13, 1968.

Read before the 25th annual meeting of the Central Surgical Association, Cleveland, Feb 23, 1968.

Reprint requests to University of Minnesota Hospitals, Minneapolis 55455 (Dr. Buchwald).

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