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Impairment and Its Relationship to Blood Trauma

V. Subramanian, MD; J. T. Lowman, MD; H. Gans, MD

AMA Arch Surg. 1968;97(2):330-335.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

DURING the past decade total or partial extracorporeal circulation has been developed to the extent that it permits repair of most lesions in and around the heart. The knowledge concerning the effect of extracorporeal circulation on the function of individual organs is unfortunately quite limited. Such information is required to understand why certain complications may occur after open-heart surgery. In addition it would provide a basis for future evaluation of technically improved methods of assisted circulation.

There are several studies of the effect of extracorporeal circulation on liver function.^1-3 All of them have been directed towards the function of the hepatocytes. No attempts to evaluate the function of the Kupffer cells have been made to our knowledge. In a previous study it was shown that hepatic reticuloendothelial function is impaired following cardiopulmonary bypass in rats.⁴ The object of the present study was to explore the possible mechanisms responsible . . . [Full Text PDF of this Article]

Author Affiliations
Minneapolis

From the departments of surgery and pediatrics, University of Minnesota Medical School, Minneapolis.

Footnotes
Submitted for publication March 18, 1968.

Read before the 25th annual meeting of the Central Surgical Association, Cleveland, Feb 23, 1968.

Reprint requests to the Department of Surgery, New York Hospital-Cornell Medical Center, New York 10021 (Dr. Subramanian).

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