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Salt Loading in Renal Aldosteronism Before and After Nephrectomy
Janos P. Radó, MD;
József Takó, MD;
Tünde Szabó, MD;
Pongrác Endes, MD;
Géza Wabrosch, MD;
Zsuzsa Szántó, MD
AMA Arch Surg. 1969;98(3):357-364.
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In the primary hyperaldosteronism discovered by Conn, a paradoxical phenomenon has been observed: in response to the rapid intravenous infusion of a hypertonic and isotonic solution of sodium chloride, diuresis increased abnormally and the urine contained a high concentration of sodium.1,2 The phenomenon has been described to occur in Cushing's syndrome,3,4 in essential hypertension,4,5 in the so-called autonomic insufficiency,6 as well as in healthy subjects treated with ganglionic blocking agents.7 In its genesis, significance has been attributed to high blood pressure,1-5 a potassium-depletion state,2 and to a loss of normal circulatory reflexes.2,6,7 It is a fact that in the patient with Conn's syndrome, the phenomenon disappears following surgical removal of the adrenal cortical adenoma.1,2 On the basis of the postoperative cessation of the increased rate of glomerular filtration evoked by the infusion, it has been suggested that in the genesis of
. . . [Full Text PDF of this Article]
Author Affiliations
Budapest
From the Isotopic Department and Metabolic Unit of the Department of Medicine, János Hospital, Budapest, and the Institute of Pathology, Medical School, Debrecen, Hungary.
Footnotes
Submitted for publication March 12, 1968.
Reprint requests to the Isotopic Department and Metabolic Unit of the Department of Medicine, János Hospital, XII. Diósárok ut 1, Budapest (Dr. Radó).
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