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Is There a Predisposition to the Development of Intestinal Malignancy?

Roger R. Dozois, MD; Edward S. Judd, MD; David C. Dahlin, MD; Lloyd G. Bartholomew, MD

AMA Arch Surg. 1969;98(4):509-517.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In 1921 in Holland, Peutz¹ first reported this interesting condition. Later, more elaborate attention was given to the syndrome by Jeghers,² and finally, in 1954, Bruwer et al³ bestowed the title of "Peutz-Jeghers syndrome" on this unusual clinical condition of mucocutaneous melanin pigmentation with coincidental intestinal polyposis.

Earlier authors^1,2,4 considered the polyps to be adenomatous, implying a possible precancerous condition. Approximately 20% of the case reports contained descriptions of malignant changes within the polyps. Later, other investigators^5-7 felt that this high incidence of malignancy resulted from misinterpretation of the peculiar nature of these polyps, which they defined as "hamartomas." This interpretation has now gained general acceptance and has been confirmed recently by electron microscopy.⁸ Isolated reports of apparent gastrointestinal tract malignancies in patients with the PeutzJeghers syndrome have stimulated further thought on the interpretation of evidence and, therefore, the proper treatment of the patients. . . . [Full Text PDF of this Article]

Author Affiliations
Rochester, Minn

From the sections of surgery (Dr. Judd), surgical pathology (Dr. Dahlin), and medicine (Dr. Bartholomew), Mayo Clinic and Mayo Foundation and the Mayo Graduate School of Medicine (University of Minnesota), Rochester (Dr. Dozois).

Footnotes
Submitted for publication Jan 7, 1969.

Read before the 76th annual meeting of the Western Surgical Association, Chicago, Nov 22, 1968.

Reprint requests to Section of Publications, Mayo Clinic, Rochester, Minn 55901.

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