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Takaharu Hayashi, MD; Urs P. Veragut, MD; Leonard L. Bailey, MD; Louis L. Smith, MD

AMA Arch Surg. 1969;99(5):645-648.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Acute respiratory insufficiency is a frequent complication in critically ill surgical patients. Support of optimal alveolar-capillary oxygen exchange becomes a primary consideration for survival. Despite the frequent occurrence of hypoxia, controversy still exists regarding its hemodynamic effects. This study was designed to determine the circulatory effects of prolonged hypoxia in dogs prior to and following acute hemorrhage. Respiration was carefully controlled throughout these experiments to prevent any change in pH or arterial carbon dioxide pressure (PCO₂) not directly attributable to hypoxia. The moderate hemorrhage (2% of body weight) employed in this study served as a challenge to test the integrity of cardiovascular function following the prolonged hypoxia.

The majority of studies reporting the circulatory effects of hypoxia have involved experimental animals subjected to severe hypoxia for brief periods of time. Under these circumstances, blood pressure rises and there is an increase in cardiac output and heart rate. Little . . . [Full Text PDF of this Article]

Author Affiliations
Loma Linda, Calif

From the Surgical Research Laboratory, Department of Surgery, Loma Linda (Calif) University School of Medicine.

Footnotes
Submitted for publication March 31, 1969.

Reprint requests to Department of Surgery, Loma Linda University School of Medicine, Loma Linda, Calif 92354 (Dr. Smith).

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