This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on Web of Science (3)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

A. Gerson Greenburg, MD; Robert B. Dreisin; George Wu; C. Frederick Kittle, MD

AMA Arch Surg. 1969;99(6):744-749.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Much attention has been directed in recent years to the effects of altered pH and partial pressure of arterial carbon dioxide (Pco₂) on the action of exogenous catecholamines and other cardiotonic drugs in the presence of hemodynamic shock.^1,2 Few references, however, are available regarding the action of isoproterenol hydrochloride in the presence of an altered acid-base status.

This laboratory study utilized an experimental format previously used to define the hemodynamic effects of altered pH and Pco₂³ and adds to it evaluation of the hemodynamic response to a single 100µg injection of isoproterenol hydrochloride. The ultimate aim of the study was to obtain more data on the mode of action of isoproterenol so that its clinical application could be better appreciated.

Methods

Male holstein calves (mean weight, 63 kg [138.6 lb]) were lightly anesthetized with ether and complete respiratory paralysis obtained with an intravenous injection of 20 . . . [Full Text PDF of this Article]

Author Affiliations
Chicago

From the Department of Surgery, Section of Thoracic and Cardiovascular Surgery, University of Chicago School of Medicine, Chicago.

Footnotes
Submitted for publication Aug 5, 1969.

Read before the 17th scientific meeting of the North American Chapter of the International Cardiovascular Society, New York, July 11, 1969.

Reprint requests to 950 E 59th St, Chicago 60637 (Dr. Greenburg).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?