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Early Detection of Canine Heart Allograft Rejection
James I. Tennenbaum, MD;
Ronald L. St. Pierre, PhD;
John S. Vasko, MD
AMA Arch Surg. 1969;99(6):753-757.
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Relatively recent surgical advances have demonstrated conclusively the technical physiologic feasibility of cardiac transplantation; however, although operatively mortality is remarkably low and short-term survival common, long-term survival has been generally disappointing because of acute and chronic rejection of the allograft which was unrelenting in the face of intensive immunosuppressive therapy. When one reviews the results of the over 100 clinical trials with human cardiac allografts performed to date, it is apparent that they have followed a course quite similar to that seen in the experimental animal. They were characterized by a remarkable immediate postoperative survival, but an almost uniform mortality within six months as a result of allograft rejection or uncontrollable infection from excessive immunosuppressive treatment. Long-term survival is substantially less than that associated with renal transplantation and may be explained in part by the fact that unlike renal transplantation where several clinical and laboratory signs of early rejection are
. . . [Full Text PDF of this Article]
Author Affiliations
Columbus, Ohio
From the departments of medicine, anatomy, and surgery, Ohio State University College of Medicine, Columbus.
Footnotes
Submitted for publication Aug 5, 1969.
Read before the 17th scientific meeting of the North American Chapter of the International Cardiovascular Society, New York, July 11, 1969.
Reprint requests to Department of Medicine, Ohio State University Hospital, 410 W Tenth Ave, Columbus, Ohio 43210 (Dr. Tennenbaum).
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